Jiemmi (Jimmy) Lin

Jiemi LinJiemmi (Jimmy) Lin

Monash University

Biography

Jimmy Lin is currently studying Bachelor of Science (Science Scholar Program) at Monash University, majoring in Applied Mathematics and Mathematical Statistics. He is particularly interested in Mathematical Biology and he finds the use of advanced mathematics in modelling complex biological systems exciting and rewarding. Jimmy is interested in not only studying mathematics, but also teaching it; he has been tutoring high school mathematics for the past three years and it has become a huge part of his life. When he is not studying or teaching mathematics, he enjoys learning foreign languages; Japanese has always been his favourite. Jimmy intends to study honours and subsequently PhD in Applied Mathematics, most likely in the field of Mathematical Biology.

Modelling the Use of Supplemental Oxygen to Combat Surgical Site Infection

Chronically infected wounds are a major burden for health care systems worldwide and a patient who suffers from this type of wound usually has a reduced quality of life. Wound infections are a common and serious complication of surgery. One of the factors that influence the incidence of surgical wound infection is the oxygen tension in tissue. Consequently, supplemental oxygen therapy is commonly used during surgery to prevent infection.A number of randomized controlled trials have investigated whether breathing 80% oxygen (compared to room conditions of 30% oxygen) during anesthesia reduces the risk of surgical site infection, post-surgery. The results are inconclusive, with two meta-analyses of trial data reaching opposite conclusions [1, 2]. This discrepancy is currently a major controversy for the care of surgical wounds during surgery.The aim of this project is to extend an existing mathematical model [3] to define the circumstances in which high levels of inspired oxygen would be expected to benefit healing and control infection post-surgery, and also to identify conditions under which it would be expected to hinder wound healing. The project will involve developing ordinary and partial differential equation models for the evolution of key cells and chemicals in the wound space over time.  The numerical solution of these equations and their analysis will provide insight into the surgical wound healing process under supplemental oxygen therapy.

References:

[1] Qadan M, Akca O, Mahid S, Hornung C, Polk Jr H (2009) Perioperative supplemental oxygen therapy and surgical site infection: a meta-analysis of randomized controlled trials. Archives of Surgery 144: 359.

[2] Togioka B, Galvagno S, Sumida S, Murphy J, Ouanes J, et al. (2012) The role of perioperative high inspired oxygen therapy in reducing surgical site infection: a meta-analysis. Anesthesia & Analgesia 114: 334-342.

[3] J Flegg, H Byrne, S McElwain, M Flegg (2012). Wound healing angiogenesis: The clinical implications of a simple mathematical model. Journal of Theoretical Biology 300: 309-316.

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