Comparison of Pre-Processing Normalisation Techniques Used in the Bioinformatic Analyses of RNA-Seq Data

Bioinformatics is the study of understanding biological systems through the analyses of large dataset which requires skills in computer science, biology and statistics. Originally it was thought that the DNA contained the information for genes (~20,000 in human), which was transcribed into RNA and then translated into proteins which form the building blocks of the cells. However, the information that codes for proteins only accounts for ~1.2% of the human genome (of the more than 3 billion base pairs) (Encode 2012) and approximately 28% in Arabidopsis thaliana (Arabidopsis Genome Initiative 2000). It is now known that there are many more RNA transcripts that are important to biological systems.

Bayan Khalili

RMIT University

Bayan Khalili is a student studying mathematics at RMIT University. He enjoys applying mathematics and statistics in a variety of settings and fields, including bioinformatics, optimisation and forecasting. He is a strong advocate of cross pollination between disciplines and wishes to collaborate with diverse teams of experts that are trying to solve complex and challenging problems.

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